[HTML][HTML] Dopamine signaling and myopia development: what are the key challenges
In the face of an “epidemic” increase in myopia over the last decades and myopia
prevalence predicted to reach 2.5 billion people by the end of this decade, there is an urgent …
prevalence predicted to reach 2.5 billion people by the end of this decade, there is an urgent …
[HTML][HTML] Dopaminergic modulation of retinal processing from starlight to sunlight
Neuromodulators such as dopamine, enable context-dependent plasticity of neural circuit
function throughout the central nervous system. For example, in the retina, dopamine tunes …
function throughout the central nervous system. For example, in the retina, dopamine tunes …
Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson's disease …
X Sánchez-Sáez, I Ortuño-Lizarán… - Translational …, 2023 - Springer
Background The main clinical symptoms characteristic of Parkinson's disease (PD) are
bradykinesia, tremor, and other motor deficits. However, non-motor symptoms, such as …
bradykinesia, tremor, and other motor deficits. However, non-motor symptoms, such as …
Dopamine differentially affects retinal circuits to shape the retinal code
RA Warwick, AS Heukamp, S Riccitelli… - The Journal of …, 2023 - Wiley Online Library
Dopamine has long been reported to enhance antagonistic surrounds of retinal ganglion
cells (RGCs). Yet, the retina contains many different RGC subtypes and the effects of …
cells (RGCs). Yet, the retina contains many different RGC subtypes and the effects of …
Parallel inhibition of dopamine amacrine cells and intrinsically photosensitive retinal ganglion cells in a non-image-forming visual circuit of the mouse retina
An inner retinal microcircuit composed of dopamine (DA)-containing amacrine cells and
melanopsin-containing, intrinsically photosensitive retinal ganglion cells (M1 ipRGCs) …
melanopsin-containing, intrinsically photosensitive retinal ganglion cells (M1 ipRGCs) …
Alteration of EIF2 signaling, glycolysis, and dopamine secretion in form-deprived myopia in response to 1% atropine treatment: Evidence from interactive iTRAQ-MS …
Purpose: Atropine, a non-selective muscarinic antagonist, effectively slows down myopia
progression in human adolescents and several animal models. However, the underlying …
progression in human adolescents and several animal models. However, the underlying …
Expression of Ca2+-Binding Buffer Proteins in the Human and Mouse Retinal Neurons
T Kovács-Öller, G Szarka, A Ganczer… - International journal of …, 2019 - mdpi.com
Ca2+-binding buffer proteins (CaBPs) are widely expressed by various neurons throughout
the central nervous system (CNS), including the retina. While the expression of CaBPs by …
the central nervous system (CNS), including the retina. While the expression of CaBPs by …
Gap junctions in A8 amacrine cells are made of connexin36 but are differently regulated than gap junctions in AII amacrine cells
In the mammalian retina, amacrine cells represent the most diverse cell class and are
involved in the spatio-temporal processing of visual signals in the inner plexiform layer. They …
involved in the spatio-temporal processing of visual signals in the inner plexiform layer. They …
Calcium buffer proteins are specific markers of human retinal neurons
O Kántor, S Mezey, J Adeghate, A Naumann… - Cell and tissue …, 2016 - Springer
Abstract Ca 2+-buffer proteins (CaBPs) modulate the temporal and spatial characteristics of
transient intracellular Ca 2+-concentration changes in neurons in order to fine-tune the …
transient intracellular Ca 2+-concentration changes in neurons in order to fine-tune the …
A tale of two neurotransmitters
DW Marshak - Visual neuroscience, 2016 - cambridge.org
Amacrine cells are a diverse set of local circuit neurons of the inner retina, and they all
release either GABA or glycine, amino acid neurotransmitters that are generally inhibitory …
release either GABA or glycine, amino acid neurotransmitters that are generally inhibitory …