Human gut microbiota is able to influence the host physiology by regulating multiple
processes, including nutrient absorption, inflammation, oxidative stress, immune function …

One of the leading causes of morbidity and premature mortality in older people is frailty.
Frailty occurs when multiple physiological systems decline, to the extent that an individual's …

Frailty is a common geriatric syndrome and strongly associated with disability, mortality and
hospitalization. Frailty is commonly measured using the frailty index (FI), based on the …

Abstract Objective To develop Clinical Practice Guidelines for the screening, assessment
and management of the geriatric condition of frailty. Methods An adapted Grading of …

Abstract Background The World Health Organization has proposed a model of healthy aging
built around the concept of functional ability, comprising an individual's intrinsic capacity, the …

The medical syndrome of frailty is widely recognized, yet debate remains over how best to
measure it in clinical and research settings. This study reviewed the frailty-related research …

The absolute and relative increases in the number of older persons are evident worldwide,
from the most developed countries to the lowest-income regions. Multimorbidity and need for …

The number of scientific publications on frailty has been increasing exponentially during the
past 15 years (Fig. 1). Studies on the topic are not limited to the geriatric and gerontology …

Aim The K ihon Checklist is extensively used in J apan to identify elderly persons who are at
risk of requiring support/care. We aimed to determine whether or not the K ihon Checklist …

Background It is estimated that about 10% of people aged 65 and older are frail. Loneliness
and social isolation are linked to increased mortality and poorer functional capacity. We …