Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression

R Wang, B Li, SM Lam, G Shui - Journal of genetics and genomics, 2020 - Elsevier
Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …

Nutrients, physical activity, and mitochondrial dysfunction in the setting of metabolic syndrome

GO Lemos, RS Torrinhas, DL Waitzberg - Nutrients, 2023 - mdpi.com
Metabolic syndrome (MetS) is a cluster of metabolic risk factors for diabetes, coronary heart
disease, non-alcoholic fatty liver disease, and some tumors. It includes insulin resistance …

n-3 polyunsaturated fatty acids in phospholipid or triacylglycerol form attenuate nonalcoholic fatty liver disease via mediating cannabinoid receptor 1/adiponectin …

Y Chen, Z Fan, X Gao, F Zhou, X Guo… - The Journal of …, 2024 - Elsevier
Abstract n-3 polyunsaturated fatty acids (PUFA) have shown to exert beneficial effects in the
treatment of nonalcoholic fatty liver disease (NAFLD). Supplements of n-3 PUFA occur in …

Omega-3 polyunsaturated fatty acids impinge on CD4+ T cell motility and adipose tissue distribution via direct and lipid mediator-dependent effects

D Cucchi, D Camacho-Munoz, M Certo… - Cardiovascular …, 2020 - academic.oup.com
Aims Adaptive immunity contributes to the pathogenesis of cardiovascular metabolic
disorders (CVMD). The omega-3 polyunsaturated fatty acids (n-3PUFA) are beneficial for …

Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors

JW Meeusen, LJ Donato, SL Kopecky, VC Vasile… - Clinica Chimica …, 2020 - Elsevier
Ceramides are bioactive lipids that act as secondary messengers for both intra-and inter-
cellular signaling. Elevated plasma concentrations of ceramides are associated with multiple …

Breast milk lipidome is associated with early growth trajectory in preterm infants

MC Alexandre-Gouabau, T Moyon, V Cariou… - Nutrients, 2018 - mdpi.com
Human milk is recommended for feeding preterm infants. The current pilot study aims to
determine whether breast-milk lipidome had any impact on the early growth-pattern of …

Omega‐3 carboxylic acids and fenofibrate differentially alter plasma lipid mediators in patients with non‐alcoholic fatty liver disease

D Camacho‐Muñoz, M Kiezel‐Tsugunova… - The FASEB …, 2021 - Wiley Online Library
Fibrates and omega‐3 polyunsaturated acids are used for the treatment of
hypertriglyceridemia but have not demonstrated consistent effects on cardiovascular (CV) …

How does CBG administration affect sphingolipid deposition in the liver of insulin-resistant rats?

W Bzdęga, PF Kurzyna, E Harasim-Symbor… - Nutrients, 2023 - mdpi.com
Background: Cannabigerol (CBG), a non-psychotropic phytocannabinoid found in Cannabis
sativa plants, has been the focus of recent studies due to its potential therapeutic properties …

Neutral sphingomyelinase‐2 and cardiometabolic diseases

S Sindhu, YH Leung, H Arefanian… - Obesity …, 2021 - Wiley Online Library
Sphingolipids, in particular ceramides, play vital role in pathophysiological processes linked
to metabolic syndrome, with implications in the development of insulin resistance, pancreatic …

Non-alcoholic fatty liver disease: Insights from sphingolipidomics

DJ Montefusco, JC Allegood, S Spiegel… - … and biophysical research …, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a major clinical concern and its treatment
consumes abundant resources. While accumulation of lipids in hepatocytes initiates the …