In the past decade, precise targeting through genome editing has emerged as a promising
alternative to traditional therapeutic approaches. Genome editing can be performed using …

The systemic administration of chemotherapeutic drugs involves some reaction and
transport mechanisms (RTM s), including perfusion along the blood vessels, extravasation …

Resistance mechanisms in brain tumors, such as medulloblastoma and glioblastoma,
frequently involve the entrapment of chemotherapeutic agents within endosomes and the …

Electroporation is a very useful tool for drug delivery into various diseased tissues of the
human body. This technique helps to improve the clinical treatment by transferring drugs into …

In recent years, the microfluidic squeezing method for cell intracellular delivery has
demonstrated high efficiency and generalizability. This approach, however, still faces …

This paper presents a mathematical model to study release dynamics of High Mobility Group
Box 1 (HMGB1) protein post-irradiation at the cellular scale. HMGB1, a damage-associated …

Background and Objective: In an in-vivo situation, the tissue near the blood vessels is rich in
oxygen supply compared to the one far from blood vessels. Hence, non-uniform oxygen …

Drug delivery through electroporation could be highly beneficial for the treatment of different
types of diseased tissues within the human body. In this work, a mathematical model of …