The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

In the tumor microenvironment (TME), tumor cells are constantly evolving to reduce
neoantigen generation and the mutational burden to escape the anti-tumor response. This …

T Regulatory cells (Tregs) act as a double-edged sword by regulating immune homeostasis
(protective role) and inhibiting immune responses in different disease settings (pathological …

Immune checkpoint inhibitors (ICIs) are starting to transform the treatment for patients with
advanced cancer. The extensive application of these antibodies for various cancer obtains …

The therapeutic potential of mesenchymal stem cells (MSCs) has been investigated in many
preclinical and clinical studies. This potential is dominantly based on the …

Background Measures of the adaptive immune response have prognostic and predictive
associations in melanoma and other cancer types. Specifically, intratumoral T cell density …

CD38 is a multifunctional cell surface protein endowed with receptor/enzymatic functions.
The protein is generally expressed at low/intermediate levels on hematological tissues and …

Immunotherapy has revolutionized the treatment of many tumors. However, most
glioblastoma (GBM) patients have not, so far, benefited from such successes. With the goal …

Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite
considerable achievements in lung cancer diagnosis and treatment, the global control of the …