The opportunistic pathogen Pseudomonas aeruginosa possesses two N-acyl-homoserine
lactone quorum-sensing systems that regulate large, overlapping sets of genes. Recent …

Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme,
contribute to DNA strand separation, and then dissociate from the core enzyme following …

Quorum sensing (QS) communication systems are thought to afford bacteria with a
mechanism to strategically cause disease. One example is Pseudomonas aeruginosa …

Pseudomonas aeruginosa is an opportunistic pathogen that causes serious illness,
especially in immunocompromised individuals. P. aeruginosa forms biofilms that contribute …

Quorum sensing signal molecules can be used to regulate the formation of biofilm, but it has
not been reported that outer membrane vesicles (OMVs) can package and mediate signal …

Pseudomonas aeruginosa uses the two major quorum-sensing (QS) regulatory systems las
and rhl to modulate the expression of many of its virulence factors. The las system is …

Considerable lung injury results from the inflammatory response to Pseudomonas
aeruginosa infections in patients with cystic fibrosis (CF). The P. aeruginosa laboratory strain …

The virulence of the opportunistic human pathogen Pseudomonas aeruginosa PAO1 is
controlled by an N-acyl-homoserine lactone (AHL)-dependent quorum-sensing system …

The administration of macrolides such as azithromycin for chronic pulmonary infection of
cystic fibrosis patients has been reported to be of benefit. Although the mechanisms of action …

Antibiotic resistance has emerged as an imminent pandemic. Rapid diagnostic assays
distinguish bacterial infections from other diseases and aid antimicrobial stewardship …