Ultrafast magic angle spinning solid-state NMR spectroscopy: Advances in methodology and applications

Y Nishiyama, G Hou, V Agarwal, Y Su… - Chemical …, 2022 - ACS Publications
Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges

PC Vioglio, MR Chierotti, R Gobetto - Advanced Drug Delivery Reviews, 2017 - Elsevier
In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

[HTML][HTML] Solid-state NMR spectroscopy in pharmaceutical sciences

M Li, W Xu, Y Su - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

Chemical shifts in molecular solids by machine learning

FM Paruzzo, A Hofstetter, F Musil, S De… - Nature …, 2018 - nature.com
Due to their strong dependence on local atonic environments, NMR chemical shifts are
among the most powerful tools for strucutre elucidation of powdered solids or amorphous …

Mechanochemistry for organic chemists: an update

D Tan, T Friščić - European Journal of Organic Chemistry, 2018 - Wiley Online Library
We provide a brief overview of recent advances in the use of mechanochemical techniques
for the synthesis of organic molecules and materials, highlighting selected examples of …

NMR crystallography of molecular organics

P Hodgkinson - Progress in Nuclear Magnetic Resonance …, 2020 - Elsevier
Developments of NMR methodology to characterise the structures of molecular organic
structures are reviewed, concentrating on the previous decade of research in which density …

Mechanochemistry: A green approach in the preparation of pharmaceutical cocrystals

M Solares-Briones, G Coyote-Dotor, JC Páez-Franco… - Pharmaceutics, 2021 - mdpi.com
Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques

E Pindelska, A Sokal, W Kolodziejski - Advanced drug delivery reviews, 2017 - Elsevier
The main goal of a novel drug development is to obtain it with optimal physiochemical,
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …

Machine-learning-guided cocrystal prediction based on large data base

D Wang, Z Yang, B Zhu, X Mei, X Luo - Crystal Growth & Design, 2020 - ACS Publications
A machine-learning model trained on the whole Cambridge Structural Database was
developed to assist high-throughput cocrystal screening. With only 2D structures taken as …

Pharmaceutical co‐crystal: An alternative strategy for enhanced physicochemical properties and drug synergy

JB Ngilirabanga, H Samsodien - Nano Select, 2021 - Wiley Online Library
A growing number of co‐crystals in the literature are proof of how significant the co‐
crystallization concept has become. Co‐crystallization enhances physicochemical …