Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …

Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline
of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype …

Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

Regulatory T cells (Tregs) are suppressive T cells that have an essential role in maintaining
the balance between immune activation and tolerance. Their development, either in the …

The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes
immunosuppression in response to infection or inflammation. Indoleamine 2, 3-dioxygenase …

Neurodegenerative disorders are characterized by excitotoxicity and neuroinflammation that
finally lead to slow neuronal degeneration and death. Although neurons are the principal …

Immune dysregulation is a hallmark of patients infected by SARS-CoV2 and the balance
between immune reactivity and tolerance is a key determinant of all stages of infection …

Over the past years, an increasing amount of evidence has emerged in support of the
kynurenine pathway's (KP) pivotal role in the pathogenesis of several neurodegenerative …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …