Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival
rates of all cancers. The bone marrow microenvironment is increasingly being recognised as …

Innate immune cells represent the first line of cellular immunity, comprised of both circulating
and tissue-resident natural killer cells and innate lymphoid cells. These innate lymphocytes …

The ability to isolate and characterize different hematopoietic stem cell (HSC) or progenitor
cell populations opens avenues to understand how hematopoiesis is regulated during …

Simple Summary Transplantation of adult hematopoietic stem cells is an important
therapeutic tool to help patients suffering from diverse hematological disorders. All types of …

Hematopoietic stem cells (HSCs) are the most primitive cell type in the hematopoietic
hierarchy, which are responsible for sustaining the lifelong production of mature blood and …

The tissue microenvironment refers to a localised tissue area where a complex combination
of cells, structural components, and signalling molecules work together to support specific …

Keratins are an integral part of cell structure and function. Here, it is shown that ectopic
expression of a truncated isoform of keratin 81 (tKRT81) in breast cancer is upregulated in …

Functional impairment of the bone marrow (BM) niche has been suggested as a major
reason for prolonged cytopenia and secondary graft failure after allogeneic hematopoietic …

Hematopoietic stem cells (HSCs), essential for lifelong blood cell regeneration, are clinically
utilized to treat various hematological disorders. These cells originate in the aortagonad …

Aging is accompanied by significant inhibition of hematopoietic and immune system function
and disruption of bone marrow structure. Aging-related alterations in the inflammatory …