Pancreatic β-cells possess an inherent ability to generate oscillatory signals that trigger
insulin release. Coordination of the secretory activity among β-cells results in pulsatile …

The mechanisms and clinical importance of pulsatile insulin release are presented against
the background of more than half a century of companionship with the islets of Langerhans …

Summary Cyclic AMP (cAMP) and Ca 2+ are key regulators of exocytosis in many cells,
including insulin-secreting β cells. Glucose-stimulated insulin secretion from β cells is …

Pulsatile secretion is an inherent property of hormone‐releasing pancreatic islet cells. This
secretory pattern is physiologically important and compromised in diabetes …

Pulsatile insulin release from glucose-stimulated β-cells is driven by oscillations of the Ca 2+
and cAMP concentrations in the subplasma membrane space ([Ca 2+] pm and [cAMP] pm) …

Diacylglycerol (DAG) controls numerous cell functions by regulating the localization of C1‐
domain‐containing proteins, including protein kinase C (PKC), but little is known about the …

Aims/hypothesis It is not clear how small tyrosine kinase inhibitors, such as imatinib
mesilate, protect against diabetes and beta cell death. The aim of this study was to …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) have a central role in pancreatic β-cell
function. Downstream events include the regulation of KATP channel activity, insulin …

To improve our understanding of the important roles played by inositol lipid derivatives in
signalling and other cellular processes, it is crucial to measure phosphoinositide …

Many effects of insulin, insulin‐like growth factors and other receptor stimuli are mediated
via the phospholipid second messenger phosphatidylinositol‐3, 4, 5‐trisphosphate (PIP 3) …