Medical case reports suggest that cannabinoids extracted from Cannabis sativa have
therapeutic effects; however, the therapeutic employment is limited due to the psychotropic …

Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Microglia, the resident immune cells of the brain, can take on a range of pro-or anti-
inflammatory phenotypes to maintain homeostasis. However, the sustained activation of pro …

The endocannabinoid system (ECS) exerts a modulatory effect of important functions such
as neurotransmission, glial activation, oxidative stress, or protein homeostasis …

Three prevalent neurodegenerative diseases, Parkinson's, Alzheimer's, and Huntington's
are in need of symptomatic relief of slowing disease progression or both. This chapter …

The discovery of cannabinoid receptors as the primary molecular targets of psychotropic
cannabinoid Δ9‐tetrahydrocannabinol (Δ9‐THC) in late 1980s paved the way for …

Parkinson's disease (PD) and l-DOPA-induced dyskinesia (LID) are motor disorders with
significant impact on the patient's quality of life. Unfortunately, pharmacological treatments …

Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a
variety of effects in the human body. They have been studied in cellular and animal models …

Parkinson's disease (PD) is characterized by severe locomotor deficits and is commonly
treated with the dopamine precursor L-DOPA, but its prolonged usage causes dyskinesias …

Parkinson's disease (PD) is the second most frequent neurodegenerative disease and
currently represents a clear unmet medical need. Therefore, novel preventive and …