Cancer remains the second most frequent cause of death in human populations worldwide,
which has been reflected in the emphasis placed on management of risk from environmental …

The repair of abasic sites that arise in DNA from hydrolytic depurination/depyrimidination of
the nitrogenous bases from the sugar–phosphate backbone and the action of DNA …

自由基反应在生命科学中扮演重要的角色. 在正常情况下, 人体内自由基的产生与清除处于平衡
状态, 从而确保人体健康. 运动时, 一系列的生化反应导致机体内清除自由基的能力不足以平衡 …

The inhibitory potency of an antisense oligonucleotide depends critically on its design and
the accessibility of its target site. Here, we used an RNA interference-guided approach to …

Conspectus DNA in its simplest form is an ensemble of nucleic acids, water, and ions, and
the conformation of DNA is dependent on the relative proportions of all three components …

Oxidation of cytosine is a leading cause of mutations and can lead to cancer. Here we report
molecular dynamics simulations that characterized the structure and flexibility of 5 …

The search for active demethylation processes lead to discovery of 5-hydroxymethylcytosine
(5hmC) adduct in the mammalian DNA. This lesion is formed post-replicatively by oxidation …

A radioterapia é uma modalidade importante para tratar o câncer de Cabeça e Pescoço, no
entanto falhas do tratamento já foram observadas e recorrência da doença é comum. Novas …

The synthesis of modified oligonucleotides is, as in previous years, divided into sections
describing updates on synthesis, followed by modifications to the backbone, sugar and …