With 100 billion neurons and 100 trillion synapses, the human brain is not just the most
complex organ in the human body, but has also been described as “the most complex thing …

The pathological alterations that manifest during the early embryonic development due to
inherited and acquired factors trigger various neurodevelopmental disorders (NDDs) …

Serotonin neurons located in the raphe nucleus of the hindbrain have crucial roles in
regulating brain functions and have been implicated in various psychiatric disorders. Yet …

Dysfunction of microRNA (miRNA) metabolism is thought to underlie diseases affecting
motoneurons. One miRNA, miR-218, is abundantly and selectively expressed by developing …

Abstract Spinal Muscular Atrophy (SMA) is caused by genetic mutations in the SMN1 gene,
resulting in drastically reduced levels of Survival of Motor Neuron (SMN) protein. Although …

Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of lower
motor neurons, which leads to proximal muscle weakness and atrophy. SMA is caused by …

Spinal muscular atrophy (SMA) is a progressive motor neuron disease caused by
deleterious variants in SMN1 that lead to a marked decrease in survival motor neuron (SMN) …

Spinal muscular atrophy (SMA) is a motor neuron disease, typically resulting from loss-of-
function mutations in the survival motor neuron 1 (SMN1) gene. Nusinersen/SPINRAZA, a …

Spinal muscular atrophy (SMA) is a kind of neuromuscular disease characterized by
progressive motor neuron loss in the spinal cord. It is caused by mutations in the survival …

Spinalmuscular atrophy (SMA) is a neuromuscular disease that affects as many as 1 in 6000
individuals at birth, making it the leading genetic cause of infant mortality. A growing number …