[HTML][HTML] Neutrophil extracellular traps (NETs) in cancer invasion, evasion and metastasis

U Demkow - Cancers, 2021 - mdpi.com
Simple Summary This review focuses on the pro-tumorigenic action of neutrophil
extracellular traps (NETs). NETs were found in various samples of human and animal …

[HTML][HTML] Autophagy as a potential therapy for malignant glioma

A Escamilla-Ramírez, RA Castillo-Rodríguez… - Pharmaceuticals, 2020 - mdpi.com
Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic
astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival …

[HTML][HTML] miRNAs as influencers of cell–cell communication in tumor microenvironment

I Conti, G Varano, C Simioni, I Laface, D Milani… - Cells, 2020 - mdpi.com
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the
posttranscriptional level, inducing the degradation of the target mRNA or translational …

Molecular and clinical insights into the invasive capacity of glioblastoma cells

C Velásquez, S Mansouri, C Mora, F Nassiri… - Journal of …, 2019 - Wiley Online Library
The invasive capacity of GBM is one of the key tumoral features associated with treatment
resistance, recurrence, and poor overall survival. The molecular machinery underlying GBM …

[HTML][HTML] The extracellular matrix in glioblastomas: a glance at its structural modifications in shaping the tumoral microenvironment—a Systematic review

S Marino, G Menna, R Di Bonaventura, L Lisi… - Cancers, 2023 - mdpi.com
Simple Summary The new trends in the research on glioblastomas (GBMs) are focusing on
understanding the crosstalk between proper neoplastic tissue and its microenvironment …

Understanding molecular signaling cascades in neural disease using multi-resolution models

NA Viswan, US Bhalla - Current opinion in neurobiology, 2023 - Elsevier
If the genome defines the program for the operations of a cell, signaling networks execute it.
These cascades of chemical, cell-biological, structural, and trafficking events span …

A 3D osteosarcoma model with bone‐mimicking cues reveals a critical role of bone mineral and informs drug Discovery

EC González Díaz, AG Lee, LC Sayles… - Advanced …, 2022 - Wiley Online Library
Osteosarcoma (OS) is an aggressive bone cancer for which survival has not improved over
three decades. While biomaterials have been widely used to engineer 3D soft‐tissue tumor …

Multiscale model of the different modes of cancer cell invasion

M Ruscone, A Montagud, P Chavrier, O Destaing… - …, 2023 - academic.oup.com
Motivation Mathematical models of biological processes altered in cancer are built using the
knowledge of complex networks of signaling pathways, detailing the molecular regulations …

[HTML][HTML] The molecular and microenvironmental landscape of glioblastomas: Implications for the novel treatment choices

F Di Cintio, M Dal Bo, L Baboci, E De Mattia… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) is the most frequent and aggressive primary central nervous system
tumor. Surgery followed by radiotherapy and chemotherapy with alkylating agents …

[HTML][HTML] Targeting chondroitin sulfate reduces invasiveness of glioma cells by suppressing CD44 and integrin β1 expression

YH Chu, WC Liao, YJ Ho, CH Huang, TJ Tseng, CH Liu - Cells, 2021 - mdpi.com
Chondroitin sulfate (CS) is a major component of the extracellular matrix found to be
abnormally accumulated in several types of cancer tissues. Previous studies have indicated …