The human brain undergoes a prolonged period of cortical development that spans multiple
decades. During childhood and adolescence, cortical development progresses from lower …

Mesocorticolimbic dopamine circuity undergoes a protracted maturation during adolescent
life. Stable adult levels of behavioral functioning in reward, motivational, and cognitive …

While there is emerging evidence of sex differences in decision-making behavior, the neural
substrates that underlie such differences remain largely unknown. Here we demonstrate that …

Across species, adolescence is a period of growing independence that is associated with
the maturation of cognitive, social, and affective processing. Reorganization of neural …

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …

During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC
development is profoundly influenced by the social environment, disruptions to which may …

Essentially all neuropsychiatric diagnoses show some degree of sex and/or gender
differences in their etiology, diagnosis, or prognosis. As a result, the roles of sex-related …

Meaningful social interactions are a fundamental human need, the lack of which can pose
serious risks to an individual's physical and mental health. Across species, peer-oriented …

Synaptic overproduction and elimination is a regular developmental event in the mammalian
brain. In the cerebral cortex, synaptic overproduction is almost exclusively correlated with …

The cellular mechanisms altered during brain wiring leading to cognitive disturbances in
neurodevelopmental disorders remain unknown. We have previously reported altered …