Embracing complexity in sepsis

AR Schuurman, PMA Sloot, WJ Wiersinga… - Critical Care, 2023 - Springer
Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of
organ systems, medical interventions and a myriad of other factors. This together results in a …

[HTML][HTML] Artificial intelligence and its impact on the domains of universal health coverage, health emergencies and health promotion: An overview of systematic reviews

A Martinez-Millana, A Saez-Saez… - International Journal of …, 2022 - Elsevier
Background Artificial intelligence is fueling a new revolution in medicine and in the
healthcare sector. Despite the growing evidence on the benefits of artificial intelligence there …

An introduction to machine learning approaches for biomedical research

J Jovel, R Greiner - Frontiers in Medicine, 2021 - frontiersin.org
Machine learning (ML) approaches are a collection of algorithms that attempt to extract
patterns from data and to associate such patterns with discrete classes of samples in the …

High-dimensional role of AI and machine learning in cancer research

E Capobianco - British journal of cancer, 2022 - nature.com
Abstract The role of Artificial Intelligence and Machine Learning in cancer research offers
several advantages, primarily scaling up the information processing and increasing the …

Current status and future directions: The application of artificial intelligence/machine learning for precision medicine

K Naik, RK Goyal, L Foschini, CW Chak… - Clinical …, 2024 - Wiley Online Library
Technological innovations, such as artificial intelligence (AI) and machine learning (ML),
have the potential to expedite the goal of precision medicine, especially when combined …

Drug development digital twins for drug discovery, testing and repurposing: a schema for requirements and development

G An, C Cockrell - Frontiers in systems biology, 2022 - frontiersin.org
There has been a great deal of interest in the concept, development and implementation of
medical digital twins. This interest has led to wide ranging perceptions of what constitutes a …

Iterative community-driven development of a SARS-CoV-2 tissue simulator

M Getz, Y Wang, G An, M Asthana, A Becker… - BioRxiv, 2021 - pmc.ncbi.nlm.nih.gov
The 2019 novel coronavirus, SARS-CoV-2, is a pathogen of critical significance to
international public health. Knowledge of the interplay between molecular-scale virus …

Digital twins for tissue culture techniques—concepts, expectations, and state of the art

J Möller, R Pörtner - Processes, 2021 - mdpi.com
Techniques to provide in vitro tissue culture have undergone significant changes during the
last decades, and current applications involve interactions of cells and organoids, three …

[HTML][HTML] A multiscale inflammatory map: linking individual stress to societal dysfunction

Y Vodovotz, J Arciero, PFMJ Verschure… - Frontiers in Science, 2024 - frontiersin.org
As populations worldwide show increasing levels of stress, understanding emerging links
among stress, inflammation, cognition, and behavior is vital to human and planetary health …

Innovations in integrating machine learning and agent-based modeling of biomedical systems

N Sivakumar, C Mura, SM Peirce - Frontiers in systems biology, 2022 - frontiersin.org
Agent-based modeling (ABM) is a well-established computational paradigm for simulating
complex systems in terms of the interactions between individual entities that comprise the …