The fruit fly, Drosophila melanogaster, has helped us to understand how innate immunity is
activated. In addition to the Toll receptor and the Toll signaling pathway, the Drosophila …

To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense
reactions, many of which are shared with higher organisms. These reactions include the use …

The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many
types of human cancer and are associated with chemoresistance, disease progression and …

The inhibitor of apoptosis (IAP) family of proteins enhances cell survival through
mechanisms that remain uncertain. In this report, we show that cIAP1 and cIAP2 promote …

The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria.
During the last two decades, significant progress has been made in identifying the …

Misregulated innate immune signaling and cell death form the basis of much human disease
pathogenesis. Inhibitor of apoptosis (IAP) protein family members are frequently …

A hallmark of the potent, multifaceted antimicrobial defence of Drosophila melanogaster is
the challenge-induced synthesis of several families of antimicrobial peptides by cells in the …

From the realization that cell number homoeostasis is fundamental to the biology of all
metazoans, and that deregulation of this process leads to human diseases, enormous …

Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

Originally described in insect viruses, cellular proteins with Baculoviral IAP repeat (BIR)
motifs have been thought to function primarily as inhibitors of apoptosis. The subsequent …