Highlights•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …

Computational methods constitute efficient strategies for screening and optimizing potential
drug molecules. A critical factor in this process is the binding affinity between candidate …

MicroRNAs (miRNAs) are attractive drug candidates for many diseases as they can
modulate the expression of gene networks. Recently, we discovered that DNAs targeting …

In alchemical free energy (FE) simulations, annihilation and creation of atoms are generally
achieved with the soft-core potential that shifts the interparticle separations. While this soft …

Bridged Nucleic Acids (BNA) or Locked Nucleic Acids (LNA) belong to a class of nucleic
acid modification that is obtained by connecting the 2'-O and 4'-C of ribose sugar using a …

A strategy named “restrained geometries and topology switching”(RGATS) is presented to
obtain detailed trajectories for complex biochemical reactions using molecular mechanics …

The protonation states for nucleic acid bases are difficult to assess experimentally. In the
context of DNA triplex, the protonation state of cytidine in the third strand is particularly …

HBV S编码链的反基因锁核酸对转基因小鼠体内病毒复制与表达的影响 主页 简体中文 English
简体中文 登录 BPG Management System F6Publishing-Submit a Manuscript F6Publishing-世界 …

Metal ions and nucleic acids are essential for a variety of biological functions. Metal ions
play roles in enzyme catalysis, signal transduction and muscle contraction, and the …

Molecular dynamics simulations with a state-of-the-art force field provide an atomistic
detailed description of the structural and thermodynamic features of biomolecules. Effects of …