Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …

Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …

CD4+ Th cells play an important role in the development of rheumatoid arthritis (RA) by
regulating adaptive immune response. As major subsets of CD4+ Th cells, Th17 cells can …

The view of CD4 T‐cell‐mediated immunity as a balance between distinct lineages of Th1
and Th2 cells has changed dramatically. Identification of the IL‐17 family of cytokines and of …

Abstract T helper 17 (Th17) cells are important mediators of immune responses against
extracellular bacteria and fungi, and as such play critical regulatory roles in maintaining …

Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes
psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic …

Since their identification in 2005, T helper (Th) 17 cells have been proposed to play
important roles in several human diseases, including various autoimmune conditions …

Regulatory T (Treg) cells are garnering increased attention in research related to
autoimmune diseases, including rheumatoid arthritis (RA). They play an essential role in the …

Objective T cell receptor (TCR) diversity determines the autoimmune responses in systemic
lupus erythematosus (SLE) and rheumatoid arthritis (RA) and is closely associated with …

IL-37, a new member of the IL-1 cytokine family, is a natural inhibitor of innate immunity
associated with autoimmune diseases. This study was undertaken to evaluate whether IL-37 …