In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …

Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …

Nrf1 is a member of the nuclear erythroid 2-like family of transcription factors that regulate
stress-responsive gene expression in animals. Newly synthesized Nrf1 is targeted to the …

Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential
and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose …

Nutrition intervention has become a potential strategy to improve healthspan and prolong
lifespan. Ginseng has been used for thousands of years and developed as a functional food …

Dysfunctional mitochondria and generation of reactive oxygen species (ROS) promote
chronic diseases, which have spurred interest in the molecular mechanisms underlying …

O‐Glc NA cylation is an essential, nutrient‐sensitive post‐translational modification, but its
biochemical and phenotypic effects remain incompletely understood. To address this …

Chicoric acid, a hydroxycinnamic acid, has been reported to possess a variety of health
benefits, including antivirus, antioxidant, anti-inflammation, obesity prevention, and …

Simple Summary Although NRF1 (nuclear factor erythroid 2-like 1; NFE2L1) and NRF2
(nuclear factor erythroid 2-like 2; NFE2L2) belong to the CNC (cap 'n'collar) transcription …

Coordination of cellular responses to stress is essential for health across the lifespan. The
transcription factor SKN-1 is an essential homeostat that mediates survival in stress-inducing …