Ligament and tendon injuries are common problems in orthopedics. There is a need for
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Background: Tendon and ligament injuries accounted for 30% of all musculoskeletal
consultations with 4 million new incidences worldwide each year and thus imposed a …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As
the human population ages and the life expectancy increases, tendon injuries will become …

Tendon formation and repair rely on specific combinations of transcription factors, growth
factors, and mechanical parameters that regulate the production and spatial organization of …

The last decade has seen significant developments in cell therapies, based on permanently
differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative …

Tendon injury is common and debilitating, and it is associated with long-term pain and
ineffective healing. It is estimated to afflict 25% of the adult population and is often a career …

Topographical cues from the extracellular microenvironment can influence cellular activity
including proliferation and differentiation. Information on the effects of material topography …

Many tissues contain adult mesenchymal stem cells (MSCs), which may be used in tissue
regeneration therapies. However, the MSC availability in most tissues is limited which …