The role of the microbiome in NAFLD and NASH

AA Kolodziejczyk, D Zheng, O Shibolet… - EMBO molecular …, 2019 - embopress.org
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of cardiometabolic
syndrome, which often also includes obesity, diabetes, and dyslipidemia. It is rapidly …

Adaptive immunity: an emerging player in the progression of NAFLD

S Sutti, E Albano - Nature Reviews Gastroenterology & Hepatology, 2020 - nature.com
In the past decade, nonalcoholic fatty liver disease (NAFLD) has become a leading cause of
chronic liver disease and cirrhosis, as well as an important risk factor for hepatocellular …

[PDF][PDF] Modulation of insulin resistance in nonalcoholic fatty liver disease

RS Khan, F Bril, K Cusi, PN Newsome - Hepatology, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) has an estimated prevalence of 25% in the general
population, and cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is predicted to …

Current and future pharmacological therapies for NAFLD/NASH

Y Sumida, M Yoneda - Journal of gastroenterology, 2018 - Springer
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and
there is no approved pharmacotherapy. The efficacy of vitamin E and pioglitazone has been …

Bovine colostrum: Its constituents and uses

RJ Playford, MJ Weiser - Nutrients, 2021 - mdpi.com
Colostrum is the milk produced during the first few days after birth and contains high levels
of immunoglobulins, antimicrobial peptides, and growth factors. Colostrum is important for …

Gut microbiome, intestinal permeability, and tissue bacteria in metabolic disease: perpetrators or bystanders?

RM Chakaroun, L Massier, P Kovacs - Nutrients, 2020 - mdpi.com
The emerging evidence on the interconnectedness between the gut microbiome and host
metabolism has led to a paradigm shift in the study of metabolic diseases such as obesity …

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

Y Rotman, AJ Sanyal - Gut, 2017 - gut.bmj.com
Given the high prevalence and rising incidence of non-alcoholic fatty liver disease (NAFLD),
the absence of approved therapies is striking. Although the mainstay of treatment of NAFLD …

Pharmacotherapy for NASH: current and emerging

MA Konerman, JC Jones, SA Harrison - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most prominent forms of
chronic liver disease worldwide, reflecting the epidemic of global obesity. Those with the …

Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

V Kumar, X Xin, J Ma, C Tan, N Osna… - Advanced drug delivery …, 2021 - Elsevier
Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

Therapies in non‐alcoholic steatohepatitis (NASH)

AM Oseini, AJ Sanyal - Liver International, 2017 - Wiley Online Library
The hallmark of non‐alcoholic fatty liver disease (NAFLD) is excessive fatty accumulation in
the hepatocytes, which may be an isolated event (non‐alcoholic fatty liver, NAFL) or …