Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …

Inhalation of silica particles is an environmental and occupational cause of silicosis, a type
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …

Proliferating hepatic stellate cells (HSC s) respond to liver damage by secreting collagens
that form fibrous scar tissue, which can lead to cirrhosis if in appropriately regulated …

Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective
treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and …

Inhalation of crystalline silica particles leads to pulmonary fibrosis, eventually resulting in
respiratory failure and death. There are few effective drugs that can delay the progression of …

As an evolutionarily conserved intracellular degradation pathway, autophagy is essential to
cellular homeostasis. Several studies have demonstrated that autophagy showed an …

Cadherin-6 (CDH6) is aberrantly expressed in cancer and closely associated with tumor
progression. However, the functions of CDH6 in human osteosarcoma and the molecular …

Silicosis remains one of the most severe pulmonary fibrotic diseases worldwide, caused by
chronic exposure to silica dust. In this review, we have proposed that programmed cell death …

Autophagy is a cellular stress response mechanism activation of which leads to degradation
of cellular components, including proteins as well as damaged organelles in lysosomes …

Fibrosis occurs in most human organs including the liver, lung, heart and kidney, and is
crucial for the progression of most chronic diseases. As an indispensable catabolic process …