Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited
pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway …

Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …

Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic
stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid …

Aged hematopoietic stem cells (HSCs) display diminished self-renewal and a myeloid
differentiation bias. However, the drivers and mechanisms that underpin this fundamental …

Hematopoietic stem cells (HSCs) are capable of entering the cell cycle to replenish the
blood system in response to inflammatory cues; however, excessive proliferation in …

Demand-adjusted and cell type specific rates of protein synthesis represent an important
safeguard for fate and function of long-term hematopoietic stem cells. Here, we identify …

Cancer and cardiovascular disease (CVD) are the two biggest killers worldwide. Specific
treatments have been developed for the two diseases. However, mutual therapeutic targets …

Inherited bone marrow failure syndromes (IBMFS) are a complex and heterogeneous group
of genetic diseases. To date, at least 13 IBMFS have been characterized. Their …

Interstrand crosslinks (ICLs) repair by the canonical Fanconi anemia (FA) pathway
generates double-strand breaks (DSBs), which are subsequently repaired by the …

Overexpression of the TGFβ pathway impairs the proliferation of the hematopoietic stem and
progenitor cells (HSPCs) pool in Fanconi anemia (FA). TGFβ promotes the expression of …