Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

[HTML][HTML] The landscape of T cell antigens for cancer immunotherapy

A Peri, N Salomon, Y Wolf, S Kreiter, M Diken… - Nature cancer, 2023 - nature.com
The remarkable capacity of immunotherapies to induce durable regression in some patients
with metastatic cancer relies heavily on T cell recognition of tumor-presented antigens. As …

Major data analysis errors invalidate cancer microbiome findings

A Gihawi, Y Ge, J Lu, D Puiu, A Xu, CS Cooper… - MBio, 2023 - Am Soc Microbiol
We re-analyzed the data from a recent large-scale study that reported strong correlations
between DNA signatures of microbial organisms and 33 different cancer types and that …

Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy

L Yang, A Li, Y Wang, Y Zhang - Signal transduction and targeted …, 2023 - nature.com
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

[HTML][HTML] Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

AM Thomas, M Fidelle, B Routy, G Kroemer… - Nature reviews Clinical …, 2023 - nature.com
Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

NN Liu, CX Yi, LQ Wei, JA Zhou, T Jiang, CC Hu… - Cancer Cell, 2023 - cell.com
Although polymorphic microbiomes have emerged as hallmarks of cancer, far less is known
about the role of the intratumor mycobiome as living microorganisms in cancer progression …

Cryptococcus neoformans, a global threat to human health

Y Zhao, L Ye, F Zhao, L Zhang, Z Lu, T Chu… - Infectious Diseases of …, 2023 - mednexus.org
Background Emerging fungal pathogens pose important threats to global public health. The
World Health Organization has responded to the rising threat of traditionally neglected …

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

Role of the microbiota in response to and recovery from cancer therapy

SJ Blake, Y Wolf, B Boursi, DJ Lynn - Nature Reviews Immunology, 2024 - nature.com
Our understanding of how the microbiota affects the balance between response to and
failure of cancer treatment by modulating the tumour microenvironment and systemic …

The global human gut microbiome: genes, lifestyles, and diet

M Parizadeh, MC Arrieta - Trends in Molecular Medicine, 2023 - cell.com
A growing number of human gut microbiome studies consistently describe differences
between human populations. Here, we review how factors related to host genetics, ethnicity …