Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

Podosomes are dynamic adhesion structures formed constitutively by macrophages,
dendritic cells and osteoclasts and transiently in a wide variety of cells, such as endothelial …

Abstract Purpose of Review The term osteopetrosis refers to a group of rare skeletal
diseases sharing the hallmark of a generalized increase in bone density owing to a defect in …

The small GTP ase Rab7 is a key organizer of receptor sorting and lysosomal degradation
by recruiting of a variety of effectors depending on its GDP/GTP‐bound state. However …

Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-
energy demand during osteoclast differentiation and bone-resorbing activities. Transferrin …

Osteopetrosis is a condition characterized by increased bone mass due to defects in
osteoclast function or formation. In the last decades, the molecular dissection of …

Osteopetrosis is a group of genetic bone disorders characterized by increased bone density
and defective bone resorption. Osteopetrosis presents a series of clinical manifestations …

Resorption of mineralized tissues like bone is accomplished by a unique cell type: the
osteoclast. This multinucleated cell has the capacity to dissolve the mineral by lowering the …