The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction
Mechanotransduction is the process by which a mechanical force, such as touch, is
converted into an electrical signal. Transmembrane channel-like (TMC) proteins are an …
converted into an electrical signal. Transmembrane channel-like (TMC) proteins are an …
Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish
Ciliated sensory cells such as photo-and olfactory receptors employ multiple types of opsins
or hundreds of unique olfactory G-protein coupled receptors to respond to various …
or hundreds of unique olfactory G-protein coupled receptors to respond to various …
Molecular specializations underlying phenotypic differences in inner ear hair cells of zebrafish and mice
Introduction Hair cells (HCs) are the sensory receptors of the auditory and vestibular
systems in the inner ears of vertebrates that selectively transduce mechanical stimuli into …
systems in the inner ears of vertebrates that selectively transduce mechanical stimuli into …
Kif1a and intact microtubules maintain synaptic‐vesicle populations at ribbon synapses in zebrafish hair cells
S David, K Pinter, KK Nguyen, DS Lee… - The Journal of …, 2024 - Wiley Online Library
Sensory hair cells of the inner ear utilize specialized ribbon synapses to transmit sensory
stimuli to the central nervous system. This transmission necessitates rapid and sustained …
stimuli to the central nervous system. This transmission necessitates rapid and sustained …
An open-source tool for automated human-level circling behavior detection
Quantitatively relating behavior to underlying biology is crucial in life science. Although
progress in keypoint tracking tools has reduced barriers to recording postural data …
progress in keypoint tracking tools has reduced barriers to recording postural data …
[HTML][HTML] Single molecule studies of the native hair cell mechanosensory transduction complex
Hearing and balance rely on the conversion of a mechanical stimulus into an electrical
signal, a process known as mechanosensory transduction (MT). In vertebrates, this process …
signal, a process known as mechanosensory transduction (MT). In vertebrates, this process …
[HTML][HTML] Transmembrane channel-like 4 and 5 proteins at microvillar tips are potential ion channels and lipid scramblases
Microvilli—membrane bound actin protrusions on the surface of epithelial cells—are sites of
critical processes including absorption, secretion, and adhesion. Increasing evidence …
critical processes including absorption, secretion, and adhesion. Increasing evidence …
Identification of Druggable Binding Sites and Small Molecules as Modulators of TMC1
The sensory hair cells of the inner ear use the mechano-electrical transducer (MET)
channels to convert the mechanical stimuli from sound or acceleration into electrical signals …
channels to convert the mechanical stimuli from sound or acceleration into electrical signals …