Delivery of bioactive molecules into the cell: the Trojan horse approach

GPH Dietz, M Bähr - Molecular and Cellular Neuroscience, 2004 - Elsevier
In recent years, vast amounts of data on the mechanisms of neural de-and regeneration
have accumulated. However, only in disproportionally few cases has this led to efficient …

Cell death in HIV dementia

MP Mattson, NJ Haughey, A Nath - Cell Death & Differentiation, 2005 - nature.com
Many patients infected with human immunodeficiency virus type-1 (HIV-1) suffer cognitive
impairment ranging from mild to severe (HIV dementia), which may result from neuronal …

The Vpr protein from HIV-1: distinct roles along the viral life cycle

E Le Rouzic, S Benichou - Retrovirology, 2005 - Springer
The genomes of human and simian immunodeficiency viruses (HIV and SIV) encode the
gag, pol and env genes and contain at least six supplementary open reading frames termed …

HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell–mediated killing

J Richard, S Sindhu, TNQ Pham… - Blood, The Journal …, 2010 - ashpublications.org
HIV up-regulates cell-surface expression of specific ligands for the activating NKG2D
receptor, including ULBP-1,-2, and-3, but not MICA or MICB, in infected cells both in vitro …

[PDF][PDF] Role of viral regulatory and accessory proteins in HIV-1 replication

A Seelamgari, A Maddukuri, R Berro, C de la Fuente… - Front Biosci, 2004 - researchgate.net
1. ABSTRACT Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired
immune deficiency syndrome (AIDS), a disease characterized by CD4+ T lymphocyte …

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells

JE Park, TS Kim, Y Zeng, M Mikolaj, J Il Ahn… - Nature …, 2024 - nature.com
HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma.
Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We …

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

EM Kilareski, S Shah, MR Nonnemacher, B Wigdahl - Retrovirology, 2009 - Springer
Human immunodeficiency virus type 1 (HIV-1) has been shown to replicate productively in
cells of the monocyte-macrophage lineage, although replication occurs to a lesser extent …

Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape

B Majumder, ML Janket, EA Schafer… - Journal of …, 2005 - Am Soc Microbiol
Antigen presentation and T-cell activation are dynamic processes involving signaling
molecules present in both APCs and T cells. Effective APC function and T-cell activation can …

An HIV-1 replication pathway utilizing reverse transcription products that fail to integrate

B Trinité, EC Ohlson, I Voznesensky, SP Rana… - Journal of …, 2013 - Am Soc Microbiol
Integration is a central event in the replication of retroviruses, yet≥ 90% of HIV-1 reverse
transcripts fail to integrate, resulting in accumulation of unintegrated viral DNA in cells …

Genealogy, expression, and molecular mechanisms in apoptosis

Z Dlamini, Z Mbita, M Zungu - Pharmacology & therapeutics, 2004 - Elsevier
Apoptosis, known as programmed cell death, is a conserved, gene-directed mechanism for
the elimination of unnecessary or unwanted cells from an organism. A retrospective look at …