The UHRF protein family in epigenetics, development, and carcinogenesis
The UHRF protein family consists of multidomain regulatory proteins that sense modification
status of DNA and/or proteins and catalyze the ubiquitylation of target proteins. Through their …
status of DNA and/or proteins and catalyze the ubiquitylation of target proteins. Through their …
Chromatin remodeling in replication‐uncoupled maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studies
M Unoki - Genes to Cells, 2021 - Wiley Online Library
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is
characterized by frequent appearance of multiradial chromosomes, which are distinctive …
characterized by frequent appearance of multiradial chromosomes, which are distinctive …
CDCA7 and HELLS suppress DNA: RNA hybrid-associated DNA damage at pericentromeric repeats
Immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome is a rare
autosomal recessive disorder that is caused by mutations in either DNMT3B, ZBTB24 …
autosomal recessive disorder that is caused by mutations in either DNMT3B, ZBTB24 …
The epigenetic machinery in the life cycle and pharmacoepigenetics
R Cacabelos, I Tellado, P Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …
expression with no structural modifications in the DNA sequence. The epigenetic machinery …
Enhanced processivity of Dnmt1 by monoubiquitinated histone H3
Y Mishima, L Brueckner, S Takahashi… - Genes to …, 2020 - Wiley Online Library
DNA methylation controls gene expression, and once established, DNA methylation patterns
are faithfully copied during DNA replication by the maintenance DNA methyltransferase …
are faithfully copied during DNA replication by the maintenance DNA methyltransferase …
Now and then in eukaryotic DNA methylation
RA Stein, FE Gomaa, P Raparla… - Physiological …, 2024 - journals.physiology.org
Since the mid-1970s, increasingly innovative methods to detect DNA methylation provided
detailed information about its distribution, functions, and dynamics. As a result, new …
detailed information about its distribution, functions, and dynamics. As a result, new …
Chemical synthesis of the ubiquitinated form of histone H3 and its effect on DNA methyltransferase 1
T Kawakami, Y Mishima, M Takazawa… - Journal of Peptide …, 2019 - Wiley Online Library
Posttranslational modifications of histone proteins, which form nucleosome cores, play an
important role in gene regulation. Ubiquitination is one such modification. We previously …
important role in gene regulation. Ubiquitination is one such modification. We previously …
Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1
RL Switzer, ZJ Hartman, GR Hewett, CF Carroll - DNA, 2023 - mdpi.com
DNA methyltransferase 1 (DNMT1) is the enzyme primarily responsible for propagation of
the methylation pattern in cells. Mutations in DNMT1 have been linked to the development of …
the methylation pattern in cells. Mutations in DNMT1 have been linked to the development of …
Enzymology of mammalian DNA methyltransferases
RZ Jurkowska, A Jeltsch - DNA Methyltransferases-Role and Function, 2022 - Springer
DNA methylation is a hot topic in basic and biomedical research. Despite tremendous
progress in understanding the structures and biochemical properties of the mammalian DNA …
progress in understanding the structures and biochemical properties of the mammalian DNA …
Then and Now in Eukaryotic DNA Methylation
RA Stein, FE Gomaa, P Raparla, L Riber - Physiological Genomics - journals.physiology.org
Then and Now in Eukaryotic DNA Methylation Page 1 1 Then and Now in Eukaryotic DNA
Methylation 1 Richard A. Stein1*, Faris E. Gomaa1, Pranaya Raparla1, and Leise Riber2 2 3 4 …
Methylation 1 Richard A. Stein1*, Faris E. Gomaa1, Pranaya Raparla1, and Leise Riber2 2 3 4 …