[HTML][HTML] Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine
Migraine is a neurological ailment that is characterized by severe throbbing unilateral
headache and associated with nausea, photophobia, phonophobia and vomiting. A full and …
headache and associated with nausea, photophobia, phonophobia and vomiting. A full and …
Advances in genetics of migraine
HG Sutherland, CL Albury, LR Griffiths - The journal of headache and pain, 2019 - Springer
Background Migraine is a complex neurovascular disorder with a strong genetic component.
There are rare monogenic forms of migraine, as well as more common polygenic forms; …
There are rare monogenic forms of migraine, as well as more common polygenic forms; …
The complexities of CACNA1A in clinical neurogenetics
MP Hommersom, TH van Prooije, M Pennings… - Journal of …, 2022 - Springer
Variants in CACNA1A are classically related to episodic ataxia type 2, familial hemiplegic
migraine type 1, and spinocerebellar ataxia type 6. Over the years, CACNA1A has been …
migraine type 1, and spinocerebellar ataxia type 6. Over the years, CACNA1A has been …
Regulation of presynaptic Ca2+ channel abundance at active zones through a balance of delivery and turnover
KL Cunningham, CW Sauvola, S Tavana, JT Littleton - Elife, 2022 - elifesciences.org
Abstract Voltage-gated Ca 2+ channels (VGCCs) mediate Ca 2+ influx to trigger
neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The …
neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The …
Eliciting presynaptic homeostatic potentiation at the Drosophila larval neuromuscular junction
The Drosophila melanogaster neuromuscular junction (NMJ) is an easily accessible
synapse and an excellent model for understanding synapse development, function, and …
synapse and an excellent model for understanding synapse development, function, and …
Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling
Synapses and circuits rely on neuroplasticity to adjust output and meet physiological needs.
Forms of homeostatic synaptic plasticity impart stability at synapses by countering …
Forms of homeostatic synaptic plasticity impart stability at synapses by countering …
Loss of activity-induced mitochondrial ATP production underlies the synaptic defects in a Drosophila model of ALS
Mutations in the gene encoding vesicle-associated membrane protein B (VAPB) cause a
familial form of amyotrophic lateral sclerosis (ALS). Expression of an ALS-related variant of …
familial form of amyotrophic lateral sclerosis (ALS). Expression of an ALS-related variant of …
Receptors and Channels Associated with Alcohol Use: Contributions from Drosophila
KM Scaplen, E Petruccelli - Neuroscience Insights, 2021 - journals.sagepub.com
Alcohol Use Disorder (AUD) is a debilitating disorder that manifests as problematic patterns
of alcohol use. At the core of AUD's behavioral manifestations are the profound structural …
of alcohol use. At the core of AUD's behavioral manifestations are the profound structural …
Zebrafish as a Model System for the Study of Severe CaV2.1 (α1A) Channelopathies
S Tyagi, AB Ribera, RA Bannister - Frontiers in Molecular …, 2020 - frontiersin.org
The P/Q-type CaV2. 1 channel regulates neurotransmitter release at neuromuscular
junctions (NMJ) and many central synapses. CACNA1A encodes the pore-containing α1A …
junctions (NMJ) and many central synapses. CACNA1A encodes the pore-containing α1A …
Distinct target-specific mechanisms homeostatically stabilize transmission at pre-and post-synaptic compartments
Neurons must establish and stabilize connections made with diverse targets, each with
distinct demands and functional characteristics. At Drosophila neuromuscular junctions …
distinct demands and functional characteristics. At Drosophila neuromuscular junctions …