1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …

Kinases are attractive anticancer targets due to their central role in the growth, survival, and
therapy resistance of tumor cells. This review explores the two primary kinase classes, the …

We have cloned and characterized a novel mammalian serine/threonine protein kinase
WNK1 (withno lysine (K)) from a rat brain cDNA library. WNK1 has 2126 amino acids and …

In this article the calcium/calmodulin-dependent protein kinases are reviewed. The primary
focus is on the structure and function of this diverse family of enzymes, and the elegant …

The emergence of acquired resistance against targeted drugs remains a major clinical
challenge in lung adenocarcinoma patients. In a subgroup of these patients we identified an …

A recent report has shown that activating mutations in the BRAF gene are present in a large
percentage of human malignant melanomas and in a proportion of colon cancers. The vast …

Protein phosphorylation, first elucidated as a regulatory mechanism in 1955, 1 is very likely
the most important mechanism for regulation in mammalian cells. While allosteric regulation …

The Saccharomyces cerevisiae FAB1 gene encodes a 257-kD protein that contains a
cysteine-rich RING-FYVE domain at its NH2-terminus and a kinase domain at its COOH …