Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Anatomic pathology studies performed over 150 years ago revealed that excessive
activation of coagulation occurs in the setting of inflammation. However, it has taken over a …

Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share
origin and many morphological and phenotypic features. However, they have different …

Oxidative stress has been defined as an imbalance between oxidants and antioxidants and
more recently as a disruption of redox signaling and control. It is generally accepted that …

Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Background Severe acute respiratory syndrome coronavirus 2 infection is associated with
hypercoagulability, which predisposes to venous thromboembolism (VTE). We analyzed …

Neutrophilic granulocytes are able to release their own DNA as neutrophil extracellular traps
(NETs) to capture and eliminate pathogens. DNA expulsion (NETosis) has also been …

Despite significant evidence implicating an important role for neutrophils in thrombosis, their
impact on the thrombotic process has remained a matter of controversy. Until 2010, platelets …

The terms microparticles (MPs) and microvesicles (MVs) refer to large extracellular vesicles
(EVs) generated from a broad spectrum of cells upon its activation or death by apoptosis …

Mechanisms of erosion have received much less attention than those that provoke plaque
rupture. Intensive statin treatment changes the characteristic of plaques that render them …