Everyday activity is based on a subtle equilibrium of excitatory and inhibitory neuronal
systems. The most prominent players in neuronal inhibition are synaptic and extrasynaptic …

The pharmacological treatment of patients with an eating disorder (ED) often includes
medications to treat their ED, comorbid mental health problems, malnutrition and the …

Objectives To investigate the relation between the risk of Alzheimer's disease and exposure
to benzodiazepines started at least five years before, considering both the dose-response …

This revision of the 2005 British Association for Psychopharmacology guidelines for the
evidence-based pharmacological treatment of anxiety disorders provides an update on key …

Objective To evaluate the association between use of benzodiazepines and incident
dementia. Design Prospective, population based study. Setting PAQUID study, France …

Benzodiazepine (BZD) inappropriate use (ie, misuse and overuse) is a worldwide public
health problem. Despite current knowledge about increased sensitivity to side effects in the …

Over the last decade there have been further developments in our knowledge of the risks
and benefits of benzodiazepines, and of the risks and benefits of alternatives to …

The term polypharmacy has negative connotations due to its association with adverse drug
reactions and falls. This spectrum of adverse events widens when polypharmacy occurs …

Background The association between long-term benzodiazepine use and risk of dementia
remains controversial. Therefore, current study aimed to quantify this association, and to …

Benzodiazepines (BZDs; including the related Z-drugs) are frequently targets for
deprescribing; long-term use in older people is harmful and often not beneficial. BZDs can …