In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …

Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …

The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in
tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we …

Abstract α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such
as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We …

Mitochondria are the only organelles regulated by two genomes. The coordinated
translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co …

Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive
fibrotic response. The latter is in large part mediated by cancer-associated fibroblasts which …

Mesothelioma is a type of late‐onset cancer that develops in cells covering the outer surface
of organs. Although it can affect the peritoneum, heart, or testicles, it mainly targets the lining …

Osteosarcoma is the most common primary malignant bone tumor with a strong tendency to
metastasize, limiting the prognosis of affected patients. Genomic, epigenomic and …

Malignant pleural mesothelioma is a rare and aggressive neoplasm, which has primarily
been attributed to the exposure to asbestos fibers (83% of cases); yet, despite a ban of using …

Malignant mesothelioma is an aggressive tumour of the pleura (MPM) or peritoneum with a
clinical presentation at an advanced stage of the disease. Current therapies only marginally …