Role of regulatory non-coding RNAs in traumatic brain injury

S Li, N Qiu, A Ni, MH Hamblin, KJ Yin - Neurochemistry international, 2024 - Elsevier
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …

MiRNA: Involvement of the MAPK pathway in ischemic stroke. A promising therapeutic target

A Gugliandolo, S Silvestro, C Sindona, P Bramanti… - Medicina, 2021 - mdpi.com
Ischemic stroke (IS) is a cerebrovascular disease with a high rate of disability and mortality. It
is classified as the second leading cause of death that arises from the sudden occlusion of …

Endothelial peroxiredoxin-4 is indispensable for blood–brain barrier integrity and long-term functional recovery after ischemic stroke

N Xu, X Jiang, W Zhang, Y Shi… - Proceedings of the …, 2024 - National Acad Sciences
The endothelial lining of cerebral microvessels is damaged relatively early after cerebral
ischemia/reperfusion (I/R) injury and mediates blood–brain barrier (BBB) disruption …

Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury

C Zhou, S Li, N Qiu, P Sun, MH Hamblin… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
The diffuse axonal damage in white matter and neuronal loss, along with excessive
neuroinflammation, hinder long-term functional recovery after traumatic brain injury (TBI) …

[HTML][HTML] Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway

Y Li, W Xue, S Li, L Cui, Y Gao, L Li, R Chen… - Biomedicine & …, 2024 - Elsevier
Aims The purpose of this study was to explore the impacts of salidroside on vascular
regeneration, vascular structural changes and long-term neurological recuperation following …

Inhibition of the JAK2/STAT3 pathway and cell cycle re‐entry contribute to the protective effect of remote ischemic pre‐conditioning of rat hindlimbs on cerebral …

Y Zhao, M Ding, F Yan, J Yin, W Shi… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims Remote ischemic pre‐conditioning (RIPC) protects against ischemia/reperfusion (I/R)
injury. However, the mechanisms underlying this protection remain unclear. In the present …

Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury

W Li, P Xu, L Kong, S Feng, N Shen, H Huang… - Translational …, 2023 - Elsevier
Angiogenesis helps to improve neurological recovery by repairing damaged brain tissue
and restoring cerebral blood flow (CBF). The role of the Elabela (ELA)-Apelin receptor (APJ) …

Role of Rph3A in brain injury induced by experimental cerebral ischemia‐reperfusion model in rats

X Zhu, H Li, W You, Z Yu, Z Wang… - CNS Neuroscience …, 2022 - Wiley Online Library
Aim The aim was to study the role of Rph3A in neuronal injury induced by cerebral ischemia‐
reperfusion. Methods The protein and mRNA levels of Rph3A in penumbra were detected by …

[HTML][HTML] Apolipoprotein E dysfunction in Alzheimer's disease: a study on miRNA regulation, glial markers, and amyloid pathology

P Wijesinghe, HR Li, Z Ai, M Campbell… - Frontiers in Aging …, 2024 - pmc.ncbi.nlm.nih.gov
Introduction Apolipoprotein E (ApoE) plays a crucial role in lipid homeostasis, predominantly
expressed in astrocytes and to a lesser extent in microglia within the central nervous system …

Electroacupuncture attenuates ischemic injury after stroke and promotes angiogenesis via activation of EPO mediated Src and VEGF signaling pathways

L Wang, G Sheng, J Cui, Y Yao, X Bai, F Chen, W Yu - Plos one, 2022 - journals.plos.org
Although electroacupuncture (EA) has been shown to be effective in the treatment of stroke,
its mechanisms of action remain undefined. This study explored the therapeutic effects of EA …