Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid
post-translational modifications that are required for the transforming activity of many …

GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and
action. Their functions depend on their ability to alternate between inactive and active forms …

Potatoes (Solanum tuberosum) contain α-solanine and α-chaconine, two well-known toxic
steroidal glycoalkaloids (SGAs). Sprouts and green tubers accumulate especially high levels …

Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …

In fungi and many other organisms, a thick outer cell wall is responsible for determining the
shape of the cell and for maintaining its integrity. The budding yeast Saccharomyces …

The Saccharomyces cerevisiae Cdc42 protein, a member of the Ras superfamily of low-
molecular-weight GTP-binding proteins, is involved in the control of cell polarity during the …

A microbial screen using a yeast strain with conditional deficiency in the GPA1 gene was
carried out to search for inhibitors of protein farnesyltransferase (PFT). A strain of …

In the yeast Saccharomyces cerevisiae, mutations in either of two unlinked genes, RAM1 or
RAM2, abolish the farnesyltransferase activity responsible for prenylation of Ras proteins …

Modular domains mediating specific protein–protein interactions play central roles in the
formation of complex regulatory networks to execute various cellular activities. Here we …

The role of HSP90 in stress tolerance was investigated in Saccharomyces cerevisiae. Cells
showing 20-fold overexpression of Hsc82, an HSP90 homologue in yeast, were …