OCT imaging of rod mitochondrial respiration in vivo

BA Berkowitz, H Qian - Experimental Biology and Medicine, 2021 - journals.sagepub.com
There remains a need for high spatial resolution imaging indices of mitochondrial respiration
in the outer retina that probe normal physiology and measure pathogenic and reversible …

pH in the Vertebrate Retina and its Naturally Occurring and Pathological Changes

AV Dmitriev, RA Linsenmeier - Progress in Retinal and Eye Research, 2024 - Elsevier
This review summarizes the existing information on the concentration of H+(pH) in
vertebrate retinae and its changes due to various reasons. Special features of H+ …

BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure

KE Guziewicz, AV Cideciyan… - Proceedings of the …, 2018 - National Acad Sciences
Mutations in the BEST1 gene cause detachment of the retina and degeneration of
photoreceptor (PR) cells due to a primary channelopathy in the neighboring retinal pigment …

Volumetric reconstruction of a human retinal pigment epithelial cell reveals specialized membranes and polarized distribution of organelles

M Lindell, D Kar, A Sedova, YJ Kim… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: Despite the centrality of the retinal pigment epithelium (RPE) in vision and
retinopathy our picture of RPE morphology is incomplete. With a volumetric reconstruction of …

[HTML][HTML] Photoreceptor layer thickness changes during dark adaptation observed with ultrahigh-resolution optical coherence tomography

CD Lu, BK Lee, J Schottenhamml… - … & Visual Science, 2017 - jov.arvojournals.org
Purpose: To examine outer retinal band changes after flash stimulus and subsequent dark
adaptation with ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods …

Decreased retinal–choroidal blood flow in retinitis pigmentosa as measured by MRI

Y Zhang, JM Harrison, OSE Nateras, S Chalfin… - Documenta …, 2013 - Springer
Purpose To evaluate retinal and choroidal blood flow (BF) using high-resolution magnetic
resonance imaging (MRI) as well as visual function measured by the electroretinogram …

Light-induced thickening of photoreceptor outer segment layer detected by ultra-high resolution OCT imaging

Y Li, RN Fariss, JW Qian, ED Cohen… - … & Visual Science, 2016 - iovs.arvojournals.org
Purpose: We examined if light induces changes in the retinal structure that can be observed
using optical coherence tomography (OCT). Methods: Normal C57BL/6J mice (age 3–6 …

Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy

BA Berkowitz, EM Grady, N Khetarpal… - … & visual science, 2015 - iovs.arvojournals.org
Purpose.: To test the hypothesis that in a mouse model of diabetic retinopathy, oxidative
stress is linked with impaired light-evoked expansion of choroidal thickness and subretinal …

[HTML][HTML] Functional changes within the rod inner segment ellipsoid in wildtype mice: an optical coherence tomography and electron microscopy study

BA Berkowitz, RH Podolsky, KL Childers… - … & visual science, 2022 - jov.arvojournals.org
Purpose: To test the hypothesis that changing energy needs alter mitochondria distribution
within the rod inner segment ellipsoid. Methods: In mice with relatively smaller (C57BL/6J …

[HTML][HTML] Mitochondrial respiration in outer retina contributes to light-evoked increase in hydration in vivo

BA Berkowitz, RH Podolsky, H Qian, Y Li… - … & Visual Science, 2018 - jov.arvojournals.org
Purpose: To test the hypothesis that mitochondrial respiration contributes to local changes in
hydration involved in phototransduction-driven expansion of outer retina, as measured by …