Maternal immune activation and neuropsychiatric illness: a translational research perspective

AS Brown, U Meyer - American Journal of Psychiatry, 2018 - Am Psychiatric Assoc
Epidemiologic studies, including prospective birth cohort investigations, have implicated
maternal immune activation in the etiology of neuropsychiatric disorders. Maternal infectious …

[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

L Bergdolt, A Dunaevsky - Progress in neurobiology, 2019 - Elsevier
The developing brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …

Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model

AC Kentner, SD Bilbo, AS Brown, EY Hsiao… - …, 2019 - nature.com
Abstract The 2017 American College of Neuropychopharmacology (ACNP) conference
hosted a Study Group on 4 December 2017, Establishing best practice guidelines to …

An overview of animal models related to schizophrenia

IR Winship, SM Dursun, GB Baker… - The Canadian …, 2019 - journals.sagepub.com
Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Maternal immune activation by poly I: C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia

FL Haddad, SV Patel, S Schmid - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Maternal immune activation (MIA) in response to a viral infection during early and mid-
gestation has been linked through various epidemiological studies to a higher risk for the …

[HTML][HTML] The dual hit hypothesis of schizophrenia: Evidence from animal models

CGJ Guerrin, J Doorduin, IE Sommer… - … & Biobehavioral Reviews, 2021 - Elsevier
Schizophrenia is a heterogeneous psychiatric disorder, which can severely impact social
and professional functioning. Epidemiological and clinical studies show that schizophrenia …

[HTML][HTML] The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to …

P Sen, E Sherwin, K Sandhu, TFS Bastiaanssen… - Brain, behavior, and …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by deficits
in social behaviour, increased repetitive behaviour, anxiety and gastrointestinal symptoms …

[HTML][HTML] Maternal immune activation in rodent models: A systematic review of neurodevelopmental changes in gene expression and epigenetic modulation in the …

RM Woods, JM Lorusso, HG Potter, JC Neill… - Neuroscience & …, 2021 - Elsevier
Maternal immune activation (mIA) during pregnancy is hypothesised to disrupt offspring
neurodevelopment and predispose offspring to neurodevelopmental disorders such as …

Bridging Autism Spectrum Disorders and Schizophrenia through inflammation and biomarkers-pre-clinical and clinical investigations

J Prata, SG Santos, MI Almeida, R Coelho… - Journal of …, 2017 - Springer
In recent years, evidence supporting a link between inflammation and neuropsychiatric
disorders has been mounting. Autism spectrum disorders (ASD) and schizophrenia share …

[HTML][HTML] Maternal behaviours and adult offspring behavioural deficits are predicted by maternal TNFα concentration in a rat model of neurodevelopmental disorders

HG Potter, HM Kowash, RM Woods, G Revill… - Brain, Behavior, and …, 2023 - Elsevier
Exposure to inflammatory stressors during fetal development is a major risk factor for
neurodevelopmental disorders (NDDs) in adult offspring. Maternal immune activation (MIA) …