Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Background In addition to decreasing the level of cholesterol, proprotein convertase subtilis
kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the …

Background The proteome is a major source of therapeutic targets. We conducted a
proteome-wide Mendelian randomization (MR) study to identify candidate protein markers …

Background & Aims The coronavirus disease 2019 (COVID-19) pandemic has witnessed
more than 4.5 million deaths as of the time of writing. Whether nonalcoholic fatty liver …

Objectives Physical inactivity and sedentary behaviour are associated with higher breast
cancer risk in observational studies, but ascribing causality is difficult. Mendelian …

Breast cancer affects one in seven women worldwide during their lifetime. Widespread
mammographic screening programs and education campaigns allow for early detection of …

Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

Background Recent research has established the correlation between gut microbiota and
periodontitis via oral-gut axis. Intestinal dysbiosis may play a pivotal bridging role in extra …

Background Some studies have shown that gut microbiota may be associated with
dementia. However, the causal effects between gut microbiota and different types of …