EDC-2: the Endocrine Society's second scientific statement on endocrine-disrupting chemicals

AC Gore, VA Chappell, SE Fenton, JA Flaws… - Endocrine …, 2015 - academic.oup.com
Abstract The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to
the scientific community about how environmental endocrine-disrupting chemicals (EDCs) …

Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome

DA Dumesic, SE Oberfield, E Stener-Victorin… - Endocrine …, 2015 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder that has both
adverse reproductive and metabolic implications for affected women. However, there is …

[HTML][HTML] Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process

NEH Mimouni, I Paiva, AL Barbotin, FE Timzoura… - Cell metabolism, 2021 - cell.com
Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder
affecting women of reproductive age. PCOS has a strong heritable component, but its …

Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models

ASL Caldwell, LJ Middleton, M Jimenez, R Desai… - …, 2014 - academic.oup.com
Polycystic ovary syndrome (PCOS) affects 5–10% of women of reproductive age, causing a
range of reproductive, metabolic and endocrine defects including anovulation, infertility …

New perspectives on the pathogenesis of PCOS: neuroendocrine origins

KA Walters, RB Gilchrist, WL Ledger, HJ Teede… - Trends in Endocrinology …, 2018 - cell.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
aged women. It is characterized by reproductive, endocrine, metabolic, and psychological …

Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

ASL Caldwell, MC Edwards, R Desai… - Proceedings of the …, 2017 - National Acad Sciences
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by
reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain …

Developmental programming, a pathway to disease

V Padmanabhan, RC Cardoso… - Endocrinology, 2016 - academic.oup.com
Accumulating evidence suggests that insults occurring during the perinatal period alter the
developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …

The sheep as a large animal model for the investigation and treatment of human disorders

A Banstola, JNJ Reynolds - Biology, 2022 - mdpi.com
Simple Summary We review the value of large animal models for improving the translation of
biomedical research for human application, focusing primarily on sheep. Abstract An …

The mechanism of androgen actions in PCOS etiology

V Rodriguez Paris, MJ Bertoldo - Medical sciences, 2019 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
age women. By comprising reproductive, endocrine, metabolic and psychological features …

A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice

AS Kauffman, VG Thackray, GE Ryan… - Biology of …, 2015 - academic.oup.com
Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack
of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat …