Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

As people live longer, ages at death are becoming more similar. This dual advance over the
last two centuries, a central aim of public health policies, is a major achievement of modern …

Theories about biological limits to life span and evolutionary shaping of human longevity
depend on facts about mortality at extreme ages, but these facts have remained a matter of …

Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

Evolution drives, and is driven by, demography. A genotype moulds its phenotype's age
patterns of mortality and fertility in an environment; these two patterns in turn determine the …

If the pace of increase in life expectancy in developed countries over the past two centuries
continues through the 21st century, most babies born since 2000 in France, Germany, Italy …

Human senescence has been delayed by a decade. This finding, documented in 1994 and
bolstered since, is a fundamental discovery about the biology of human ageing, and one …

Fig. 1. Record female life expectancy from 1840 to the present [suppl. table 2 (1)]. The linear-
regression trend is depicted by a bold black line (slope= 0.243) and the extrapolated trend …