Antibody responses to viral infections: a structural perspective across three different enveloped viruses
CD Murin, IA Wilson, AB Ward - Nature microbiology, 2019 - nature.com
Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …
through the dual role of antibodies in communicating the presence of invading pathogens in …
[HTML][HTML] Viral membrane fusion: a dance between proteins and lipids
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …
members of high concern for global human health. All enveloped viruses have a dedicated …
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection
Broadly neutralizing antibodies (bnAbs) to coronaviruses (CoVs) are valuable in their own
right as prophylactic and therapeutic reagents to treat diverse CoVs and as templates for …
right as prophylactic and therapeutic reagents to treat diverse CoVs and as templates for …
[HTML][HTML] Structural basis for broad coronavirus neutralization
Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier
in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the …
in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the …
[HTML][HTML] Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections
HA Parray, S Shukla, R Perween, R Khatri… - Applied microbiology …, 2021 - Springer
The route of administration of a therapeutic agent has a substantial impact on its success.
Therapeutic antibodies are usually administered systemically, either directly by intravenous …
Therapeutic antibodies are usually administered systemically, either directly by intravenous …
[HTML][HTML] Longitudinal analysis of the human B cell response to Ebola virus infection
Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …
[HTML][HTML] Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection
Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic
approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have …
approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have …
[HTML][HTML] On the road to ending the COVID-19 pandemic: Are we there yet?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged into the human
population in late 2019 and caused the global COVID-19 pandemic. SARS-CoV-2 has …
population in late 2019 and caused the global COVID-19 pandemic. SARS-CoV-2 has …
Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV
SA Ehrhardt, M Zehner, V Krähling, H Cohen-Dvashi… - Nature medicine, 2019 - nature.com
Recombinant vesicular stomatitis virus–Zaire Ebola virus (rVSV-ZEBOV) is the most
advanced Ebola virus vaccine candidate and is currently being used to combat the outbreak …
advanced Ebola virus vaccine candidate and is currently being used to combat the outbreak …
[HTML][HTML] Antibody-dependent enhancement of Ebola virus infection by human antibodies isolated from survivors
Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can
protect against infection. It is currently unknown whether natural infection also induces some …
protect against infection. It is currently unknown whether natural infection also induces some …