Exerting its actions pre‐, post‐and peri‐synaptically, brain‐derived neurotrophic factor
(BDNF) is one of the most potent modulators of hippocampal synaptic function. Here, we …

Dysfunctions of neuronal and network excitability have emerged as common features in
disorders associated with intellectual disabilities, autism, and seizure activity, all common …

Brain‐derived neurotrophic factor (BDNF) is well known as a survival factor during brain
development as well as a regulator of adult synaptic plasticity. One potential mechanism to …

Neurons communicate through the exocytotic release of transmitters from presynaptic axon
terminals and the ensuing activation of postsynaptic receptors. Instantaneous responses of …

Following the classical work on presynaptic inhibition in the spinal cord, recent work has
revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors …

In searching for persistent seizure-induced alterations in brain function that might be
causally related to epilepsy, presynaptic transmitter release has relatively been neglected …

Significance Two-photon (2p) microscopy has historically relied on titanium sapphire pulsed
lasers that are expensive and have a large footprint. Recently, several manufacturers have …

Inhibitory control of local neuronal circuits is critical for prefrontal cortical functioning.
Modulation of inhibitory circuits by several neuromodulators has been demonstrated, but the …

γ-Aminobutyric acid type A (GABA A) receptors, a family of Cl--permeable ion channels,
mediate fast synaptic inhibition as postsynaptically enriched receptors for γ-aminobutyric …

Background NMDA receptors are traditionally viewed as being located postsynaptically, at
both synaptic and extrasynaptic locations. However, both anatomical and physiological …