Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved
process and aberrant pyruvate metabolism is associated with and contributes to numerous …

Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product
of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy …

This work was designed to comparatively investigate 27 dietary flavonoids that act as α-
glucosidase inhibitors and insulin sensitizers. On the basis of the results of an in vitro …

The mitochondrial pyruvate carrier (MPC) is an inner mitochondrial membrane complex that
plays a critical role in intermediary metabolism. Inhibition of the MPC, especially in liver, may …

Atherosclerosis is the hallmark of cardiovascular disease (CVD) which is a leading cause of
death in type 2 diabetes patients, and glycemic control is not beneficial in reducing the …

A hepatic comorbidity of metabolic syndrome, known as nonalcoholic fatty liver disease
(NAFLD), is increasing in prevalence in conjunction with the pandemics of obesity and …

Thiazolidinedione (2, 4‐TZD), commonly known as glitazone, is a ubiquitous heterocyclic
pharmacophore possessing a plethora of pharmacological activities and offering a vast …

The liver coordinates the systemic response to nutrient deprivation and availability by
producing glucose from gluconeogenesis during fasting and synthesizing lipids via de novo …

The mitochondrial pyruvate carrier (MPC) occupies a central metabolic node by transporting
cytosolic pyruvate into the mitochondrial matrix and linking glycolysis with mitochondrial …

As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays
a pivotal role in many physiological and pathological processes across the human lifespan …