Alterations in glutamatergic neurotransmission are implicated in the pathophysiology of
depression, and the glutamatergic system represents a treatment target for depression. To …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date …

Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social
interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR …

Glutamate is the primary excitatory neurotransmitter in the mammalian brain. Glutamatergic
neurotransmission may be modulated at multiple levels, only a minority of which are …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Major depressive disorder (MDD) is a common, chronic, recurrent mental illness that affects
millions of individuals worldwide. To date, the monoaminergic systems (serotonin …

Fragile X Syndrome is the most common form of inherited mental retardation worldwide. A
Fragile X mouse model, fmr1tm1Cgr, with a disruption in the X-linked Fmr1 gene, has three …

Objective: Clinical and preclinical evidence suggests a hyperactive glutamatergic system in
clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been …

Alcoholism is a major public health problem and resembles, in many ways, other chronic
relapsing medical conditions. At least 2 separate dimensions of its symptomatology offer …