Causal associations of sleep apnea with Alzheimer disease and cardiovascular disease: a bidirectional Mendelian randomization analysis
Background Sleep apnea (SA) has been linked to an increased risk of dementia in
numerous observational studies; whether this is driven by neurodegenerative, vascular, or …
numerous observational studies; whether this is driven by neurodegenerative, vascular, or …
simmrd: An open‐source tool to perform simulations in Mendelian randomization
Mendelian randomization (MR) has become a popular tool for inferring causality of risk
factors on disease. There are currently over 45 different methods available to perform MR …
factors on disease. There are currently over 45 different methods available to perform MR …
MVMRmode: Introducing an R package for plurality valid estimators for multivariable Mendelian randomisation
Background Mendelian randomisation (MR) is the use of genetic variants as instrumental
variables. Mode-based estimators (MBE) are one of the most popular types of estimators …
variables. Mode-based estimators (MBE) are one of the most popular types of estimators …
Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence
ZR Liu, YY Wang, SH Wang, JX Wu… - Skin Research and …, 2024 - Wiley Online Library
Background The genetic association between urticaria and mental disorders and whether
inflammatory cytokines mediate this process remains unclear. Materials and methods A …
inflammatory cytokines mediate this process remains unclear. Materials and methods A …
Inference of causal and pleiotropic effects with multiple weak genetic instruments: application to effect of adiponectin on type 2 diabetes
PM McKeigue, A Iakovliev, A Spiliopoulou, B Erabadda… - medRxiv, 2023 - medrxiv.org
Current methods for Mendelian randomization studies have several limitations: to construct
unlinked genetic instruments they can use only one SNP from each clump of exposure …
unlinked genetic instruments they can use only one SNP from each clump of exposure …
Drug-target Mendelian randomisation applied to metabolic dysfunction-associated steatotic liver disease: opportunities and challenges
S Luo, MH Zheng, VWS Wong… - …, 2024 - egastroenterology.bmj.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most
prevalent cause of chronic liver disease worldwide affecting over one-third of the adult …
prevalent cause of chronic liver disease worldwide affecting over one-third of the adult …
An application of the MR-Horse method to reduce selection bias in genome-wide association studies of disease progression
Genome-wide association studies (GWAS) of disease progression are vulnerable to collider
bias caused by selection of participants with disease at study entry. This bias introduces …
bias caused by selection of participants with disease at study entry. This bias introduces …
Disentangling the causal effects of education and participation bias on Alzheimer's disease using Mendelian Randomization
Introduction: People with university degrees have a lower incidence of Alzheimer's Disease
(AD). However, the relationship between education and AD could be due to selection …
(AD). However, the relationship between education and AD could be due to selection …
Research Synthesis Methodology for Normative Data and Genetic Data
W Cao - 2023 - search.proquest.com
A reference interval represents the normative range for measurements from a healthy
population. It can be interpreted as a prediction interval for a new individual from the overall …
population. It can be interpreted as a prediction interval for a new individual from the overall …
Developing and applying new tools to study complex disease risk
N Lorincz-Comi - 2024 - rave.ohiolink.edu
Mendelian Randomization (MR) is a popular tool used to estimate causal effects of
exposures on complex disease risk. Many existing MR methods cannot accommodate …
exposures on complex disease risk. Many existing MR methods cannot accommodate …