Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Microelectromechanical systems (MEMS) are essential components in many electronic
technologies for consumer and industrial applications. Such devices are typically made …

Engineering complex tissues and whole organs has the potential to dramatically impact
translational medicine in several avenues. Organ engineering is a discipline that integrates …

Metastasis requires tumor cells to navigate through a stiff stroma and squeeze through
confined microenvironments. Whether tumors exploit unique biophysical properties to …

Biochemical signaling and mechano-transduction are both critical in regulating stem cell
fate. How crosstalk between mechanical and biochemical cues influences embryonic …

Mechanical forces are now recognized as key cellular effectors that together with genetic
and cellular signals physically shape and pattern tissues and organs during development …

Background: The role of increased smooth muscle cell (SMC) integrin αv signaling in Marfan
syndrome (MFS) aortic aneurysm remains unclear. Herein, we examine the mechanism and …

Motile cells navigate through tissue by relying on tactile cues from gradients provided by
extracellular matrix such as ligand density or stiffness. Mesenchymal stem cells (MSCs) and …

Abstract Background The Pharyngeal Endoderm (PE) is an extremely relevant
developmental tissue, serving as the progenitor for the esophagus, parathyroids, thyroids …

Cell fate determination, a vital process in early development and adulthood, has been the
focal point of intensive investigation over the past decades. Its importance lies in its critical …