Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the
pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine …

The diagnosis of chronic pancreatitis remains challenging in early stages of the disease.
This report defines the diagnostic criteria useful in the assessment of patients with suspected …

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long
thought to be the primary causative agent, but genetic contributions have been of interest …

Emerging data in the past few years suggest that acute, recurrent acute (RAP), and chronic
pancreatitis (CP) represent a disease continuum. This review discusses the similarities and …

Chronic pancreatitis is an inflammatory disorder of the pancreas. We analyzed CPA1,
encoding carboxypeptidase A1, in subjects with nonalcoholic chronic pancreatitis (cases) …

Chronic pancreatitis (CP) is characterized by progressive pancreatic damage that eventually
results in significant impairment of exocrine as well as endocrine functions of the gland. In …

Abstract Background The American College of Medical Genetics and Genomics (ACMG)-
recommended five variant classification categories (pathogenic, likely pathogenic, uncertain …

BACKGROUND & AIMS:: Alcohol has been implicated in the development of chronic
pancreatitis (CP) in 60%–90% patients, although percentages in the United States are not …

Chronic pancreatitis is a persistent inflammatory disease of the pancreas, in which the
digestive protease trypsin has a fundamental pathogenetic role. Here we have analyzed the …