Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Skeletal muscle stem cells have a central role in muscle growth and regeneration. They
reside as quiescent cells in resting muscle and in response to damage they transiently …

Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …

Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially …

Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions
among several types of cells. A noticeable aspect of skeletal muscle biology is the drastic …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

Adaptation to mechanical load, leading to enhanced force and power output, is a
characteristic feature of skeletal muscle. Formation of new myonuclei required for efficient …

The “canonical” function of Pax7+ muscle stem cells (satellite cells) during hypertrophic
growth of adult muscle fibers is myonuclear donation via fusion to support increased …

Abstract Background Satellite cells (SCs) are required for muscle repair following injury and
are involved in muscle remodeling upon muscular contractions. Exercise stimulates SC …

Skeletal muscle is a plastic tissue that regenerates ad integrum after injury and adapts to
raise mechanical loading/contractile activity by increasing its mass and/or myofiber size, a …