Avian species have long struggled with the problem of coccidiosis, a disease that affects
various parts of the intestine, including the anterior gut, midgut, and hindgut. Among different …

Apicomplexans are a group of pathogenic protists that cause various diseases in humans
and animals that cause economic losses worldwide. These unicellular eukaryotes are …

Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …

Periodic fever is a characteristic clinical feature of human malaria, but how parasites survive
febrile episodes is not known. Although the genomes of Plasmodium species encode a full …

Malaria parasites have a complex life cycle featuring diverse developmental strategies, each
uniquely adapted to navigate specific host environments. Here we use single-cell …

Gametocytogenesis, the process by which malaria parasites produce sexual forms that can
infect mosquitoes, is essential for the transmission of malaria. A transcriptional switch of the …

Malaria transmission requires that some asexual parasites convert into sexual forms termed
gametocytes. The initial stages of sexual development, including sexually committed …

Background Plasmodium parasites undergo several major developmental transitions during
their complex lifecycle, which are enabled by precisely ordered gene expression programs …

Abstract Development of the malaria parasite, Plasmodium falciparum, is regulated by a
limited number of sequence-specific transcription factors (TFs). However, the mechanisms …

Differentiation from asexual blood stages to mature sexual gametocytes is required for the
transmission of malaria parasites. Here, we report that the ApiAP2 transcription factor, PfAP2 …